8 research outputs found

    Cellular system information capacity change at higher frequencies due to propagation loss and system parameters

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    In this paper, mathematical analysis supported by computer simulation is used to study cellular system information capacity change due to propagation loss and system parameters (such as path loss exponent, shadowing and antenna height) at microwave carrier frequencies greater than 2 GHz and smaller cell size radius. An improved co-channel interference model, which includes the second tier co-channel interfering cells is used for the analysis. The system performance is measured in terms of the uplink information capacity of a time-division multiple access (TDMA) based cellular wireless system. The analysis and simulation results show that the second tier co-channel interfering cells become active at higher microwave carrier frequencies and smaller cell size radius. The results show that for both distance-dependent: path loss, shadowing and effective road height the uplink information capacity of the cellular wireless system decreases as carrier frequency increases and cell size radius R decreases. For example at a carrier frequency fc = 15.75 GHz, basic path loss exponent α = 2 and cell size radius R = 100, 500 and 1000m the decrease in information capacity was 20, 5.29 and 2.68%

    The evolving SARS-CoV-2 epidemic in Africa: Insights from rapidly expanding genomic surveillance

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    INTRODUCTION Investment in Africa over the past year with regard to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing has led to a massive increase in the number of sequences, which, to date, exceeds 100,000 sequences generated to track the pandemic on the continent. These sequences have profoundly affected how public health officials in Africa have navigated the COVID-19 pandemic. RATIONALE We demonstrate how the first 100,000 SARS-CoV-2 sequences from Africa have helped monitor the epidemic on the continent, how genomic surveillance expanded over the course of the pandemic, and how we adapted our sequencing methods to deal with an evolving virus. Finally, we also examine how viral lineages have spread across the continent in a phylogeographic framework to gain insights into the underlying temporal and spatial transmission dynamics for several variants of concern (VOCs). RESULTS Our results indicate that the number of countries in Africa that can sequence the virus within their own borders is growing and that this is coupled with a shorter turnaround time from the time of sampling to sequence submission. Ongoing evolution necessitated the continual updating of primer sets, and, as a result, eight primer sets were designed in tandem with viral evolution and used to ensure effective sequencing of the virus. The pandemic unfolded through multiple waves of infection that were each driven by distinct genetic lineages, with B.1-like ancestral strains associated with the first pandemic wave of infections in 2020. Successive waves on the continent were fueled by different VOCs, with Alpha and Beta cocirculating in distinct spatial patterns during the second wave and Delta and Omicron affecting the whole continent during the third and fourth waves, respectively. Phylogeographic reconstruction points toward distinct differences in viral importation and exportation patterns associated with the Alpha, Beta, Delta, and Omicron variants and subvariants, when considering both Africa versus the rest of the world and viral dissemination within the continent. Our epidemiological and phylogenetic inferences therefore underscore the heterogeneous nature of the pandemic on the continent and highlight key insights and challenges, for instance, recognizing the limitations of low testing proportions. We also highlight the early warning capacity that genomic surveillance in Africa has had for the rest of the world with the detection of new lineages and variants, the most recent being the characterization of various Omicron subvariants. CONCLUSION Sustained investment for diagnostics and genomic surveillance in Africa is needed as the virus continues to evolve. This is important not only to help combat SARS-CoV-2 on the continent but also because it can be used as a platform to help address the many emerging and reemerging infectious disease threats in Africa. In particular, capacity building for local sequencing within countries or within the continent should be prioritized because this is generally associated with shorter turnaround times, providing the most benefit to local public health authorities tasked with pandemic response and mitigation and allowing for the fastest reaction to localized outbreaks. These investments are crucial for pandemic preparedness and response and will serve the health of the continent well into the 21st century

    Minimum cell size for information capacity increase in cellular wireless network

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    In this paper results of mathematical analysis supported by simulation are used to find a theoretical limit for cell size reduction in mobile communication systems. Information capacity approach is used for the analysis. Attention is given to the active co-channel interfering cells. Because at microwave frequencies beyond 2 GHz, co-channel interfering cells beyond the first tier becomes dominant as the cell size reduces. We show that when the cell size limit is reached any further reduction in cell size will not increase the information capacity of the cellular network. A formula is derived for calculating the number of co-channel cells in subsequent tiers
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